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Staphylococcus aureus and Pseudomonas aeruginosa are infamous for causing an extensive spectrum of infections, varying from minor skin to severe systemic diseases. The rate of these infections has added significant difficulty in treating infectious diseases. The epidemiological data on these infections show considerable variation due to differences in population samples, and geographical regions with an estimate prevalence of up to 53 million individuals worldwide harbor methicillin-resistant S. aureus infections. Methicillin-resistant S. aureus and carbapenem-resistant P. aeruginosa exhibit similar multiple resistance mechanisms to antibiotics, however, the outer membrane permeability is a unique feature of gram-negative bacteria. The common resistance mechanisms include altering penicillin-binding proteins, activating efflux systems, and β-lactamase enzyme production, significantly reducing antibiotics' efficacy. For controlling and preventing the transmission of these resistant pathogens diagnostic tests are essential, they play a significant role in screening and monitoring specific infections. They are rapid and necessary for implementing effective infection control measures.
Rexe et al. (Fri,) studied this question.