August 28, 2024Open Access

Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells

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Abstract

We have previously demonstrated the significant reliance of pancreatic Cancer Stem Cells (PaCSCs) on mitochondrial oxidative phosphorylation (OXPHOS), which enables versatile substrate utilization, including fatty acids (FAs). Notably, dysregulated lipid scavenging and aberrant FA metabolism are implicated in PDAC progression.

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Mascaraque et al. (Wed,) studied this question.

synapsesocial.com/papers/68e5a818b6db6435875425bd https://doi.org/https://doi.org/10.1186/s12967-024-05598-6

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