The research aims to develop and evaluate a spectrophotometric method to quantify, amlodipine in pharmaceutical formulations. The method demonstrated ,high sensitivity with a molar, absorptivity of 69,744.87 L·mol⁻¹·cm⁻¹ and a Sandell's sensitivity, of 8.51×10⁻⁶ μg·cm⁻². Linearity was observed in the range ,of 1.0-10 μg/ml, with a correlation coefficient (R²) of 0.9984. The detection limit (LOD) was, calculated as 0.0987 μg·ml⁻¹ and, the quantitative limit (LOQ) , was found to be 0.2991 μg·ml⁻¹. Precision and accuracy were, determined by testing three different concentrations of amlodipine, resulting in relative standard deviations (RSD%) ranging from 0.21-1.01% and relative errors (RE%) between,(-2 to 1%). The method was successfully applied to commercial pharmaceutical products, demonstrating recovery range of 101.42-103.40%. This study provides a reliable and efficient analytical approach, for assessing amlodipine, in various pharmaceutical, formulations.
Abdullah et al. (Tue,) studied this question.