Segmentation of Substantia Nigra, Subthalamic and Red Nuclei with a Multi-Modal Quantitative 7T MRI High Resolution Template

The segmentation of brain substructures is very useful in the characterization of alterations involved in multiple diseases. From 200 7T brain MRI scan including MP2RAGE and MGRE used to generate quantitative T1 maps (qT1), R2* and QSM volumes, a pipeline was developed to create a high-resolution multi-modal template at (400 µm)3 based on these multiple quantitative imaging modalities. Preliminary results show that multi-modality allows for a more precise parcellation of the SN, RN and STH substructures.