Key points are not available for this paper at this time.
This study compared age-related differences in white matter morphology and microstructure across ten major tracts of the human brain using diffusion data from 535 participants of the Human Connectome Project in Aging. The results are additionally assessed for agreement with retrogenesis predictions of white matter decline in normal aging. While whole-brain relationships between morphometry and white matter integrity were identified, high variability was also observed between tracts. While our data do not fully support retrogenesis models, we demonstrate patterns that may provide partial support, and highlight the need for tract-specific studies of morphological-microstructural interactions in the aging white matter.
Robinson et al. (Wed,) studied this question.