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The aging process of the human brain is known to be complex, resulting in considerable structural and functional changes in the brain. In this study, a brain age prediction method based on QSM was proposed and then applied to predict the brain age of PD patients. The model achieved a high prediction accuracy with the MAE of 4.40 years and the R2 of 0.91 in healthy subjects. The PADs of the PD patients were significantly higher than HC subjects. The results show that brain age prediction based on QSM can provide a new biomarker to explore iron-related brain age changes.
Chen et al. (Wed,) studied this question.
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