Abnormal glymphatic system function in patients with chronic migraine using diffusion tensor image analysis along the perivascular space

Chronic migraine (CM) is a common and highly disabling primary headache associated with vasomotion dysfunction. It is unclear whether glymphatic dysfunction develops due to frequent and chronic headache attacks in CM. In the current study, we evaluated the glymphatic system function in patients with CM using diffusion tensor image analysis along the perivascular space (DTI-ALPS) technique. We found a significantly higher ALPS index compared with healthy controls, and the alteration was significant only observed in the right hemisphere. Patients with CM have abnormalities in glymphatic function, and the right-prominent alterations might be a certain feature of CM.