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Although multiple MRI-based myelin marker have been introduced, their sensitivity and specificity remained limited. Multi-parametric MRI can potentially enhance myelin mapping, but validation remains challenging. In this study, we compared myelin histology from the Gli1-/- mouse brain, which has enhanced myelination, with MRI markers based on relaxation, magnetization transfer, and diffusion properties from the same animals. We found varying degrees of correlation between MRI markers and myelin basic protein signals in multiple brain regions. Partial least square regression analysis demonstrated that multi-parametric MRI can indeed improve myelin mapping and provided information for further optimization.
Lee et al. (Wed,) studied this question.