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Nigral hyperintensity detection in substantia nigra is a potential biomarker for PD. An advanced SWI method, SMWI, has demonstrated reliable detection of the hyperintensity at 3T but it requires a 4 m 15 s scan protocol which is too long for PD patients, suffering from motion artifacts. In this study, we developed a new 2 m 56 s protocol by reducing phase FOV and applying deep learning-powered denoising to compensate for SNR loss from the shorter scan. The new protocol was validated using both simulated and real data via an automated tool and an expert radiologist.
Youn et al. (Wed,) studied this question.
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