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Accurately staging squamous cell carcinoma (SCC) is of vital importance for determining the treatment plan, prognosis and outcome. Diffusion-relaxation correlation spectrum imaging (DR-CSI) can jointly encode diffusion and relaxation information and resolve information of tissue compartments and heterogeneity at a sub-voxel level. In this study we investigated the feasibility of DR-CSI in characterizing tissue microenvironment and staging SCC. The DR-CSI technique can non-invasively provide information on microscopic tissue compartments within voxels, reflecting intra-tissue heterogeneity. The diagnostic performance of DR-CSI in identifying early and advanced SCC was significantly superior to conventional ADC and T2.
Gao et al. (Wed,) studied this question.
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