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This study investigated the feasibility of IMPULSED(Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion) to evaluate cell microstructure of head and neck squamous cell carcinoma. The results showed that mean cell diameter, extracellular diffusion coefficient and intracellular volume fraction are 9.47±3.33 µm,1.95±1.04μm²/ms and 0.23±0.14% respectively and consistent with the previous pathological reports. Patients with cervical lymph node metastases had significantly smaller mean cell diameters than those without metastases. Mean cell diameter decreased with increasing cycles of immunotherapy. This suggests that IMPULSED can quantitatively characterize cell properties of tumor in head and neck squamous cell carcinoma patients.
Liu et al. (Wed,) studied this question.