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Interrelationships between T1 relaxation time and axon fibre orientation in midsagittal corpus callosum (CC) were studied in human brain in vivo at 3T and 7T as well as in a rat brain ex vivo at 9.4T. It was observed that in the same CC tracts in vivo the change in T1 results from altered fibre orientation with respect to B0. In the rat brain, ex vivo rotation of a given midsagittal CC ROI produced angular T1 plots that match those observed in vivo. Thus, axon fibre orientation is directly linked to T1 relaxation anisotropy.
Kauppinen et al. (Wed,) studied this question.
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