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The potential for DMI measurements of deuterated glucose metabolism to differentiate between metabolic subtypes in GBM has been demonstrated in patient-derived xenografts in mice. The glycolytic subtype showed increased lactate labelling whereas two oxidative subtypes showed increased glutamate/glutamine (Glx) labelling. There was decreased lactate labelling in a glycolytic subtype and decreased lactate and Glx labelling in an oxidative subtype within 24 h after the completion of standard-of-care chemoradiotherapy, demonstrating that the technique can also be used to detect early treatment response in this tumor type.
Low et al. (Wed,) studied this question.