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129Xe MRS measures static and dynamic spectral parameters from 129Xe signal in airspaces, membrane tissues, and red blood cells (RBC) and has the potential to characterize cardiopulmonary diseases. However, a better understanding of measurement repeatability is needed, and different approaches to quantifying cardiogenic oscillations have been proposed. Here, we compare quantification of oscillations using sine-fitting and a peak-finding algorithm and use reader ratings to identify acceptable study quality. Across a range of cardiopulmonary disease groups, measurements of static parameters showed good intra-session repeatability while the peak-finding algorithm generally yielded higher repeatability than sine fits for most dynamic parameters.
Bechtel et al. (Wed,) studied this question.