Amide proton transfer-weighted MRI of brain tumors with fluid & solid compartment corrections using background magnetization transfer effects

We propose a simple and efficient metric for APT-weighted MRI, which suppresses fluid signals and enhances signals form solid components based on the spectral shape of the background MT ratio. No extra acquisition or mathematical fitting is needed because the metric can be computed from the minimum Z-spectral data required for standard APT-weighted MRI. This post-processing normalizing for background MT effects may facilitate the quantitative evaluation of the APT-weighted signal of the active solid component in brain tumors.