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T1rho imaging has been used to probe relatively slow macromolecular processes, making it a practical tool to gain information about water spin dynamics and interactions with endogenous macromolecules. We measured the dispersion of T1rho with different spin-lock fields in the intervertebral disc of swine spine specimens before and after the treatment to induce proteoglycan loss, a sign of early disc degeneration. Analysis revealed elevated T1rho values in all proteoglycan-depleted discs at each spin-lock field, and that post-treatment T1rho changes increase at a higher spin-lock field.
Christiansen et al. (Wed,) studied this question.