Glioma grading using multiparametric MRI: head-to-head comparison among four different advanced techniques

Diagnostic performances differentiating low-grade (LGGs) from high-grade gliomas (HGGs) were compared between the four advanced techniques of multiparametric MRI—DSC, DCE, MRS and DWI. Sixty-four patients with pathologically confirmed glioma underwent preoperative multiparametric MRI with the four techniques, followed by histogram analysis of the tumors. HGGs showed significantly higher Ktrans, rCBV, and Cho/Cr than LGGs. The AUROC of the 95th percentile Ktrans was 0.83, being the most helpful parameter, followed by 95th percentile rCBV (0.72). Significant correlations were observed between the 95th percentile rCBV and Ktrans. Our findings demonstrate higher diagnostic utility of DCE and DSC MRI in glioma grading.