Feasibility of Performing High-Resolution Multi-delay PCASL Imaging with Intravascular Signal Suppression Within 7 Minutes

To ensure satisfactory perfusion signal-to-noise ratio (SNR) for ASL imaging, intravascular perfusion signals are typically not suppressed (e.g., high-resolution multi-delay SMS/MB-EPI PCASL imaging for Human Connectome Projects) but can induce significant bias for CBF quantification if not addressed sufficiently. Recently proposed image denoising methods may be able to improve ASL imaging quality and SNR, having the potential to making it practical to perform ASL imaging with intravascular signal suppression. Our preliminary study results suggested that with image denoising, high-resolution multi-delay SMS/MB-EPI PCASL imaging with intravascular suppression could be achieved within 7 minutes.