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Modafinil is a psychostimulant primarily used to manage sleep disorders, multiple sclerosis, and both unipolar and bipolar depression. Despite the risk of precipitating mania and psychosis, it is also employed as a non-antipsychotic augmentation therapy in schizophrenia. Only two case reports documented managing mania and narcolepsy with co-prescribed lithium carbonate. Below we discuss a case of treatment-induced mania in a gentleman diagnosed with Bipolar Affective Disorder (BPAD) comorbid with type I narcolepsy who was prescribed modafinil, venlafaxine and fluoxetine. The successful mood stabilisation with lithium carbonate suggests a potential role for mood stabilisers in such cases. This case report underscores the complexity of treating narcolepsy with comorbid psychiatric conditions and the importance of comprehensive evaluation and tailored management.
Galea et al. (Sat,) studied this question.