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Objective: The aim of this study was to evaluate pediatric patients with celiac disease (CD) compliant with gluten-free diet (GFD) by age groups and determine the relationship between the duration of compliance with diet, anthropometric measurements, and laboratory parameters.Methods: A total of 195 children with CD (mean age: 7.3±4.4,male/female: 0.69) who were compliant with GFD were enrolled in this retrospective study.Clinical and demographic characteristics, laboratory examinations, serological tests, histopathological findings, and genetic analysis of the patients were examined according to age groups at diagnosis, 6 months, and 1 st and 2 nd years of follow-up.Results: 19.5% of the patients were ≤2 years old, and most of the patients were between 5 and 9 years of age.68.2% of the patients were typical, 26.2% were atypical, and 5.6% were asymptomatic.The most common presenting symptoms were growth retardation, diarrhea, and abdominal distension in children ≤2 years of age.When the patients were classified according to height and weight standard deviation scores, no statistically significant differences were observed during follow-up (p>0.05).As the duration of compliance to GFD increased, the number of patients who were normal and overweight increased.Additionally, significant differences were observed in body mass index Z-scores among age groups during follow-up. Conclusion:Growth retardation, diarrhea, and abdominal distension are the predominant symptoms in infants.As age increases, atypical presentation becomes more common.Longer the duration of compliance with GFD, improvement in anthropometric measurements and laboratory parameters are more prominent.
Abanoz et al. (Tue,) studied this question.