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Introduction: Vitamin D plays a very important role in the human body. It affects bone health, immune system function, and is responsible for overall well-being. Vitamin D deficiency is a common worldwide. It contributes to the development of osteoporosis, cardiovascular diseases, and autoimmune disorders and many others. This article reviews the current state of knowledge about vitamin D deficiency, its causes, health consequences, diagnostic methods, and treatment options, with a particular focus on the effectiveness of calcifediol in treating this deficiency. Aim of the Study: The aim of this study was to summarize the current state of knowledge about vitamin D, vitamin D deficiency, its causes of health consequences, diagnostic methods, and treatment options, with a particular focus on the efficacy of calcifediol. Materials and Methods: The literature available in the PubMed database was reviewed using the following keywords: "vitamin D deficiency", "calcifediol treatment", "vitamin D metabolism", "epidemiology of vitamin D deficiency", "vitamin D diagnostic criteria", "calcifediol". Conclusions: Vitamin D plays an important role in maintaining bone health, supporting the immune system and regulating various physiological processes. However, despite its importance, vitamin D deficiency is widespread, affecting populations around the world due to factors such as limited sun exposure, dietary habits and certain health conditions. Calcifediol has become particularly effective treatment of vitamin D deficiency due to its higher bioavailability and faster performance compared to other forms, such as cholecalciferol.
Gmitrzuk et al. (Fri,) studied this question.