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Spatial genomics uncovers hotspots of transcriptomic changes associated with glucocorticoid receptor signaling. A, Visualization of spatial gene expression of key genes correlated with the neighborhood violent crime rate in representative tumor samples from high and low-violence neighborhoods. Spatial expression was visualized in Seurat. B, Hot spot analysis of key genes correlated with the violent crime rate in representative tumor samples from high and low-violence neighborhoods. Hotspots were identified using the univariate local Moran’s test. Darker colors denote a P-value of P-value of C, Pathway analysis of genes differentially expressed within P P-value of P-value of
Heath et al. (Wed,) studied this question.