Analysis of promising directions for improving the methodological part of the biological monitoring system at potentially hazardous chemical facilities (analytical review)

Introduction. Currently in the Russian Federation, the practice of industrial medicine does not use methods of biological monitoring of organic compounds – an addition to industrial control, which consists in regularly measuring the content of biomarkers of harmful chemicals in the body of workers. The purpose of the study is to analyze available scientific publications and methodological documents on biomarkers of harmful organic substances, to draw conclusions about the directions for the development of methodological support for biological monitoring of organic compounds in the Russian Federation. Material and methods. available scientific publications, methodological guidelines of Rospotrebnadzor, materials of the Russian Register of Potentially Hazardous Chemical and Biological Substances, and foreign methodological documents, in particular from the Agency for Toxic Substances and Disease Registry, USA, were used. Results. A list of the most common harmful organic substances circulating at hazardous chemical facilities, their biomarkers and methods for measuring them in biological media was compiled. An analysis of domestic and foreign hygienic standards for the content of toxicants or their markers in biological media was performed. Limitations. The analytical review of biological monitoring methods was carried out only for organic compounds and does not include inorganic substances. Conclusion. The analytical review made it possible to identify the following necessary methodological elements for the implementation of biological monitoring in the Russian Federation: the development of at least 9 chemical-analytical methods for determining biomarkers in the biological environments of workers, the introduction of immunochromatographic methods when conducting biological monitoring of workers to clarify the reliability of anamnesis data on attitudes towards alcohol, smoking and medications, experimental studies on the detection and identification of biomarkers of exposure to a number of organic compounds, experimental substantiation of hygienic standards for the content of 15 substances in the air of the working area.