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Abstract The goal of the proposed research work is to establish and validate an uncomplicated, as well as precise RP-HPLC and UV Spectrophotometric technique to detect Dapagliflozin in both API as well as tablet form. At ambient temperature, the concentrations of Dapagliflozin were measured using an RP HPLC (λ = 225) and UV system (λ = 278). For method development Phenomenex Luna® LC C18 Column (150 × 4.6mm, 5µm) was used. Acetonitrile and water (65:35) were used as mobile phase. The standard Dapagliflozin medication is eluted at a 1.0 ml/min flow rate. The recoveries ranged from 98 to 103%, according to the regression coefficient values of 0.999 for the UV spectrophotometric method and 0.9994 for the RP-HPLC method. The statistical parameters, ± RSD, and recoveries in this investigation demonstrated how successful the RP-HPLC and UV system is at separating and identifying different compounds. It was also determined that Dapagliflozin in bulk and dose forms may be routinely monitored for quality using this technology.
Mahabole et al. (Wed,) studied this question.