June 4, 2024Open Access

Supplementary Figure S11 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

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Abstract

Figure S11 – Summary of HuAR9.6 Proposed Mechanism of Action. . In summary, huAR9.6 mAb binds with MUC16 positive PDAC and reduces tumor growth via 1) inhibiting the activation of MUC16-mediated ErbB signaling, and 2) inducing antibody-dependent cytotoxicity (ADCC) and 3) complement-dependent cytotoxicity (CDC).

Supplementary Figure S11 from Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6

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Abstract

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