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The present study focuses on tailoring the relative content of Fe3+ and Fe2+ ions incorporation into hydroxyapatite (HA) lattice, employing a hydrothermal approach in a closed vessel to minimize Fe2+ oxidation and secondary phase formation. Citrate molecules are used to regulate nanoparticle formation/stability, creating a mild reducing environment, while the impact of a stronger reducing agent, hydroxylamine, is explored. Fe3+ insertion was found to be less favoured than Fe2+, possibly due to charge imbalance. Iron doping significantly alters stoichiometry and crystallinity of HA, with Fe3+ enhancing OH- depletion. Morphological analysis reveals differences among samples, as induced by the different Fe ions incorporation: particularly Fe2+ ion incorporation is found to maintain rod-like structures, which changes upon Fe3+ presence. Overall, this study provides insights into controlled doping of HA with iron ions, vital for developing stable, redox-responsive nanomaterials applicable in cancer therapy and other applications where surface activity plays a relevant role.
Pupilli et al. (Fri,) studied this question.