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Three Schiff bases (1a, 1b, and 1c) have been prepared from the reaction of o-vanillin with primary amine (aniline, p-toluidine, and p-anisidine). Schiff base derivates from o-vanillin were synthesized using the grinding method for 20 minutes. Physical properties were observed based on color, melting point, and solubility. Synthesis products were also characterized using FTIR, GCMS, 1H-NMR, and 13C-NMR. The antioxidant activity of the Schiff base was tested using DPPH. While the toxicity test uses the BSLT method. The result of this synthesis and characterization Schiff base (1a, 1b, and 1c) showed that the Schiff base compound was formed into 2-methoxy-6 (phenyliminomethyl) phenol; 2-methoxy-6- (((4-methylphenyl) imino) methyl) phenol; and 2-methoxy-6-(((4-methoxyphenyl) imino) methyl) phenol. The result of NMR analysis, on 1H-NMR spectrum showed the shift chemical at 8,5-8,6 ppm which indicates the typical peak of proton (-HC=N-). Meanwhile, the 13C-NMR spectrum shown the shift chemical at 160-162 ppm which indicates the typical peak of carbon (-C=N-). The result of antioxidant activity showed that all Schiff base was antioxidant quite low ability with value of EC50 is 106.2-196.4 ppm. Meanwhile, the result of toxicity test showed that all Schiff base was anticancer with an LC50 value of 9.99-22.29 ppm.
Hanapi et al. (Mon,) studied this question.