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Autoimmune diseases pose a multifaceted challenge in the realm of medical science, warranting innovative approaches for their management. Resveratrol, a naturally ccurring compound found in various dietary sources, has captured attention for its potential immunomodulatory and anti-inflammatory properties. Understanding the interplay between autoimmune diseases and resveratrol is crucial for exploring novel therapeutic avenues. This review aims to explore the intricate relationship between autoimmune diseases and resveratrol. It seeks to provide insights into the mechanistic underpinnings of autoimmune diseases, emphasizing the necessity for innovative therapeutic interventions. Additionally, it aims to comprehensively discuss the pharmacological properties of resveratrol and its potential applications in managing autoimmune diseases. A structured review approach was employed to organize the content into distinct sections. Extensive literature searches were conducted to gather information on autoimmune diseases, the pharmacology of resveratrol, and its effects on immune regulation, inflammation, and oxidative stress. Experimental and clinical evidence regarding the efficacy of resveratrol in managing specific autoimmune diseases was critically evaluated. Resveratrol demonstrates immunomodulatory, anti-inflammatory, and antioxidant effects, which are relevant to autoimmune disease management. These properties impact immune cell regulation, pro-inflammatory cytokines, inflammatory mediators, and oxidative stress, potentially ameliorating autoimmune pathogenesis. Clinical studies present promising evidence for the efficacy of resveratrol in conditions such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and inflammatory bowel disease, albeit further research is necessary to determine its safety and optimal dosages. The review underscores the promising potential of resveratrol in autoimmune disease management. By targeting key pathways implicated in autoimmunity, resveratrol holds promise as an adjunctive or standalone therapy. Future research endeavors should concentrate on addressing lingering questions, refining dosages and delivery systems, investigating combination therapies, and facilitating the translation of findings into clinical practice. Resveratrol emerges as a valuable avenue for advancing therapeutic strategies in autoimmune diseases.
Jetha et al. (Wed,) studied this question.