1045 Sleep Disorders in Pediatric Patients with Agenesis of the Corpus Callosum

Abstract Introduction Agenesis of the corpus callosum (ACC) is a complete or partial absence of the corpus callosum arising from disruption of brain development. There is limited information about sleep in children with ACC. We aim to describe the sleep architecture and respiratory parameters of children with ACC. Methods Retrospective study of 20 patients with ACC who had polysomnography (PSG) between 2000-2023. Demographic data, BMI or weight for length (percentile), associated conditions, and PSG findings were collected. Sleep quality was compared to the National Sleep Foundation’s guidelines. Poor sleep quality indicators were sleep latency 45 min, sleep efficiency (SE) 75%, N1 ≥20%, N2 81%, N3 ≤5% for 14-17 years, N3 ≤10% for 14 years, REM ≤10% excluding 6-13 year-olds, or arousal index 10/h. Fisher’s exact test or unpaired t-test was used to compare groups. Results Average age was 5.9 ± 5.4 years old, and 12/20 patients were male. 6/20 were overweight/obese. 14/20 had complete ACC, and 6/20 had partial ACC. 8/20 had seizures. 15/20 had ≥1 poor sleep quality indicator, notably decreased SE (45%) , decreased REM (53%), and increased arousals (45%). Between complete and partial ACC, there was no difference in presence of ≥1 poor sleep quality indicator (p= 0.61), SE (p=0.34), REM (p=0.28), and arousals (p=1). Sleep quality was similar between seizure and no seizure groups (p=0.60). 11/18 had obstructive sleep apnea (OSA); 5/11 also had central sleep apnea (CSA). 1/20 had CSA alone. Only 1 with OSA was overweight. Excluding patients with tracheostomies, there was no difference in OSA between those with complete and partial ACC (p=1) or those with and without seizures (p=0.16). SpO2 baseline was 95 ± 2%; SpO2 nadir was 85 ± 0.1%. 4/20 had ≥5 minutes of total sleep time (TST) with SpO2 90%. PETCO2 maximum was 48 ± 5 mmHg; none had PETCO2 50mmHg for 25% of TST. Conclusion Children with ACC have poor sleep quality, and many have OSA. There was no difference in sleep quality or presence of OSA between those with complete and partial ACC. Our study supports the need for screening of sleep-related disorders in patients with ACC. Support (if any)