0955 Correlation Between CPAP Use and Symptoms of Depression, Anxiety, and Sleepiness in Patients with OSA

Abstract Introduction Obstructive Sleep Apnea (OSA) is a prevalent sleep disorder associated with poor health outcomes, including sleepiness, anxiety, and depression. This study aimed to further explore this relationship by looking at outcomes after treatment of OSA with continuous positive airway pressure (CPAP) therapy, using the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7), and Epworth Sleepiness Scale (ESS) questionnaires respectively. Methods An observational longitudinal study in which the PHQ-9, GAD7, and ESS questionnaires were administered to adult patients diagnosed with OSA during the initial consultation and after three months of CPAP use. All patients had a diagnosis of OSA by a sleep study. Data collected included demographics, PSG data, and questionnaire results. Patients without follow-up or incomplete data were not included. Results One hundred patients were initially recruited. Thirty-five patients have completed data after three months. The mean±SD age was 50.9±15.4, BMI 36.5±8.9, 54% male and 46% female. Women were older 61.1±14 than men 46.5±14.9, p 0.001. The percent of CPAP adherence was 68.7±36.7, and hours used per day were 5.5±1.8. The PHQ-9 initially was 10.4±5.6 decreased to 5.32±5.3 p 0.001. GAD-7 initially 6.4±6.2 decreased to 4.29±4.8 p 0.001, ESS initially 11.1±5.5 decreased to 5.8±4.3 p 0.001. Neither age, BMI, or AHI correlated with compliance or hours used. The strongest negative correlation was between post-treatment GAD-7 and compliance (r= -0.45), followed by a mild negative correlation between PHQ-9 and compliance (r = -0.345). A mild positive correlation existed between the initial ESS and the AHI (r = 0.288). There were no statistical differences in questionnaire results between men and women. Conclusion The study demonstrates that daytime symptoms of sleepiness, depression, and anxiety improved in a cohort of patients with OSA and CPAP. The post-CPAP GAD-7 was moderately and negatively correlated with CPAP compliance percent use, while PHQ-9 was mildly negatively correlated. Initial ESS was mildly correlated with AHI, and although it improved, it was not correlated with compliance. Support (if any)