Mp48-06 Paclitaxel Coated Ureteral Balloon for Ureteroscopic Thermal Injury Induced Ureteral Stenosis in Porcine Model: A Preclinical Study

You have accessJournal of UrologyReconstruction: Ureteral Reconstruction (Including Pyeloplasty) and Bladder Reconstruction (Including Trauma-Related Fistula) I (MP48)1 May 2024MP48-06 PACLITAXEL COATED URETERAL BALLOON FOR URETEROSCOPIC THERMAL INJURY INDUCED URETERAL STENOSIS IN PORCINE MODEL: A PRECLINICAL STUDY Xinfei Li, Peng Zhang, Fangzhou Zhao, Zhihua Li, Liqing Xu, Kunlin Yang, and Xuesong Li Xinfei LiXinfei Li , Peng ZhangPeng Zhang , Fangzhou ZhaoFangzhou Zhao , Zhihua LiZhihua Li , Liqing XuLiqing Xu , Kunlin YangKunlin Yang , and Xuesong LiXuesong Li View All Author Informationhttps://doi.org/10.1097/01.JU.0001009512.15743.d7.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To explore the safety and effectiveness of paclitaxel coated ureteral balloon in porcine model. METHODS: This study conducted a total of 6 pigs. The control group consisted of 3 pigs who only underwent ureteroscopic thermal injury induced stenosis, while the experimental group consisted of 3 pigs who underwent ureteroscopic thermal injury induced stenosis, followed by paclitaxel coated ureteral balloon on one side and plain balloon on the other side. We measured the drug concentration in the blood and local tissues immediately and 4 weeks after balloon dilation as a safety evaluation, and perioperative complications was another safety indicator. The effectiveness was evaluated by retrograde angiography of the lumen diameter. RESULTS: All procedures were successfully completed except for one pig with left ureteral occlusion that was unable to perform ordinary balloon dilation. No complications occurred during the perioperative period. At 28 days after surgery, the average drug concentration in the ureteral segment tissue after balloon dilation was 51.1 ng/mg. The concentration of paclitaxel in the blood immediately after balloon dilation and 28 days after surgery was below the quantification limit. The normal ureteral diameter was 6.1±0.5 mm, and the diameter of luminal stenosis was 2.8±1.0 mm, and it had increased to 5.6±1.1 mm after paclitaxel coated balloon dilation, which restored 91.8% of the baseline level. The initial effect was better than that of plain balloons (normal diameter: 6.6±0.1 mm, stenosis diameter: 1.5±0.3 mm, after dilation: 2.2±0.4 mm). CONCLUSIONS: Paclitaxel coated ureteral balloon is safe for ureteral stenosis. Compared with plain balloons, the stenosis site had smoother luminal diameters. Therefore, paclitaxel coated balloon has good clinical application prospects for the treatment of ureteral stenosis. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e774 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Xinfei Li More articles by this author Peng Zhang More articles by this author Fangzhou Zhao More articles by this author Zhihua Li More articles by this author Liqing Xu More articles by this author Kunlin Yang More articles by this author Xuesong Li More articles by this author Expand All Advertisement PDF downloadLoading ...