Mp41-08 Utilizing Patient-Reported Outcomes to Assess the Impact of Universal Germline Genetic Testing for Prostate Cancer

You have accessJournal of UrologyProstate Cancer: Markers I (MP41)1 May 2024MP41-08 UTILIZING PATIENT-REPORTED OUTCOMES TO ASSESS THE IMPACT OF UNIVERSAL GERMLINE GENETIC TESTING FOR PROSTATE CANCER Neal Shore, Christopher M. Pieczonka, Sean Heron, Mukaram Gazi, David J. Cahn, Laurence Belkoff, Aaron D. Berger, Brian Mazzarella, David Morris, Joseph Veys, Richard Bevan-Thomas, Alexander Engelman, Paul Dato, Robert Cornell, David R. Wise, Mary Kay Hardwick, Kathryn E. Hatchell, Brandie Heald, Robert L. Nussbaum, Sarah M. Nielsen, and Edward D. Esplin Neal ShoreNeal Shore , Christopher M. PieczonkaChristopher M. Pieczonka , Sean HeronSean Heron , Mukaram GaziMukaram Gazi , David J. CahnDavid J. Cahn , Laurence BelkoffLaurence Belkoff , Aaron D. BergerAaron D. Berger , Brian MazzarellaBrian Mazzarella , David MorrisDavid Morris , Joseph VeysJoseph Veys , Richard Bevan-ThomasRichard Bevan-Thomas , Alexander EngelmanAlexander Engelman , Paul DatoPaul Dato , Robert CornellRobert Cornell , David R. WiseDavid R. Wise , Mary Kay HardwickMary Kay Hardwick , Kathryn E. HatchellKathryn E. Hatchell , Brandie HealdBrandie Heald , Robert L. NussbaumRobert L. Nussbaum , Sarah M. NielsenSarah M. Nielsen , and Edward D. EsplinEdward D. Esplin View All Author Informationhttps://doi.org/10.1097/01.JU.0001008896.93851.5b.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Germline genetic testing (GGT) affords prostate cancer (PCa) patients (pts) opportunities for targeted therapies, personalized management, and cascade family testing. Patient-reported outcomes (PRO) evaluate physician effectiveness in promoting pt test comprehension and clinical decision making, which are essential components of GGT. PROs from a large prospective PCa study were analyzed. METHODS: The PROCLAIM trial (NCT05447637) enrolled unselected PCa pts from 15 US urology practices. Pts underwent 84-gene GGT at Invitae® with PROs collected >1-month post-GGT. PROs were analyzed overall and by GGT result: positive (≥1 pathogenic germline variant), negative, and variant(s) of uncertain significance (VUS). Differences in proportions were determined using two-tailed Fisher's exact test and significance was set at 1 clinical recommendation from their physician, most (76%) had completed or planned to complete >1 of them (Table 1). Positive pts who complied with recommendations were more likely to have demonstrated comprehension of their GGT result compared to pts who were non-compliant (p=0.006). Most pts reported that their GGT result either reduced (42%) or did not impact (51%) their concern regarding their PCa diagnosis, treatment or followup. 7% of all patients, and 18% of positive patients, reported increased concern. CONCLUSIONS: Implementation of universal GGT for PCa did not appear to cause undue harm to pts and resulted in adherence to clinical recommendations. There still remains educational opportunities to improve how test results and recommendations are communicated to pts. Source of Funding: Invitae Corp © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e675 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Neal Shore More articles by this author Christopher M. Pieczonka More articles by this author Sean Heron More articles by this author Mukaram Gazi More articles by this author David J. Cahn More articles by this author Laurence Belkoff More articles by this author Aaron D. Berger More articles by this author Brian Mazzarella More articles by this author David Morris More articles by this author Joseph Veys More articles by this author Richard Bevan-Thomas More articles by this author Alexander Engelman More articles by this author Paul Dato More articles by this author Robert Cornell More articles by this author David R. Wise More articles by this author Mary Kay Hardwick More articles by this author Kathryn E. Hatchell More articles by this author Brandie Heald More articles by this author Robert L. Nussbaum More articles by this author Sarah M. Nielsen More articles by this author Edward D. Esplin More articles by this author Expand All Advertisement PDF downloadLoading ...