Mp45-09 Low Sulfate and Low Urinary Volume Are Associated With an Increased Risk of Recurrent Stone Events

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation II (MP45)1 May 2024MP45-09 LOW SULFATE AND LOW URINARY VOLUME ARE ASSOCIATED WITH AN INCREASED RISK OF RECURRENT STONE EVENTS Rei Unno, Heiko Yang, Wilson Sui, David Bayne, Marshall Stoller, and Thomas Chi Rei UnnoRei Unno , Heiko YangHeiko Yang , Wilson SuiWilson Sui , David BayneDavid Bayne , Marshall StollerMarshall Stoller , and Thomas ChiThomas Chi View All Author Informationhttps://doi.org/10.1097/01.JU.0001008764.86460.8e.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To understand the metabolic factors impacting the recurrent stone events in high-risk stone formers. METHODS: This was an analysis of 24-hour urine collections linked to prospectively collected clinical data from the Registry for Stones of the Kidney and Ureter (ReSKU) at a single institution between 2015 and 2022. 24-hour urine collections were administered to all consecutive patients with high-risk features as defined by the AUA guidelines or by patient preference. Urine parameters were considered abnormal based on the values provided by Litholink™. Demographic and clinical information, including subsequent stone events during the follow-up period, was collected. Univariate and multivariate logistic regression analyses were performed to identify the factors associated with the recurrent stone events. RESULTS: Of 2114 patients analyzed, 619 (29.2%) underwent at least one 24-hour urine test. Patients undergoing metabolic evaluation were more often highly educated, non-smokers, had a history of hyperlipidemia and prior stones, and had a positive family history of urolithiasis. Of the 619 patients completing a 24-hour urine test, 163 (26.3%) experienced at least 1 stone event over a median follow-up period of 6 months. On univariate analyses, younger age, female gender, history of smoking or previous stones, low urinary sulfate levels, and high supersaturation of calcium phosphate were associated with an increased risk of stone events. On multivariate analyses controlling for demographics including age, gender, history of smoking, and history of prior stones, low urine volume and low urinary sulfate were significantly associated with an increased odds of recurrent stone events (odds ratio 1.76, 95% confidence interval 1.06-2.92, p=0.03, 2.00, 1.10-3.64, 0.022, respectively) (Table 1). CONCLUSIONS: In stone patients who underwent 24-hour urine testing, low urinary volume and low sulfate were independent metabolic factors associated with recurrent stone events. Further studies examining the mechanism by which this occurs are warranted. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e745 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Rei Unno More articles by this author Heiko Yang More articles by this author Wilson Sui More articles by this author David Bayne More articles by this author Marshall Stoller More articles by this author Thomas Chi More articles by this author Expand All Advertisement PDF downloadLoading ...