V11-01 TUTORIAL AND Case SERIES: URETHRAL PACLITAXEL-COATED BALLOON DILATION

You have accessJournal of UrologyBPH/Male Voiding Dysfunction/Infection/Misc. Imaging (V11)1 May 2024V11-01 TUTORIAL AND Case SERIES: URETHRAL PACLITAXEL-COATED BALLOON DILATION Kendrick Campbell, Fernandino L. Vilson, Sajya Singh, Alethea Paradis, Joel Vetter, and Gregory Murphy Kendrick CampbellKendrick Campbell , Fernandino L. VilsonFernandino L. Vilson , Sajya SinghSajya Singh , Alethea ParadisAlethea Paradis , Joel VetterJoel Vetter , and Gregory MurphyGregory Murphy View All Author Informationhttps://doi.org/10.1097/01.JU.0001009368.07681.43.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We present a tutorial video on urethral paclitaxel-coated balloon dilation as requested by the Core Curriculum and offer a case series to help guide further research. Our case series examines use of urethral paclitaxel-coated balloon dilation to further delineate how stricture etiology, length, and location affect treatment success given that guidelines are predominantly based upon a cohort with mostly bulbar urethral strictures and low incidence of radiation induced strictures. METHODS: We preformed deidentified retrospective chart review on men who underwent urethral paclitaxel-coated balloon dilation at our institution from October 2022 to August 2023. Hazard ratios were run on etiology of stricture, stricture length, and stricture location. RESULTS: 53 patients in total were reviewed. Average age was 61.3±16.8 years. 56.6% of patients scored≥2 on the Charlson Comorbidity Index. 49.1% of patients had history of UTI. 67.9% had history of prior endoscopic treatment; 37.7% had history of prior urethroplasty; and many patients had undergone multiple treatments prior to urethral paclitaxel-coated balloon dilation. Etiology of strictures varied but the most common was radiation (28.3%), followed by iatrogenic (18.9%), and then trauma and hypospadias (each 11.3). Other/unknown accounted for 30.2%. Most strictures were in the bulbar urethra (49.2%), followed by the membranous urethra (29.5%), then the penile urethra (21.3%), and bladder neck (8.2%). Some strictures spanned multiple locations. Stricture length was 29.5±27.6 millimeters. In accordance with the location and size of our strictures, the 30 french balloon was used more frequently and the balloon length was most often 5 centimeters. 39.7% of patients underwent concurrent direct visualization internal urethrotomy. 52.8% of patients reported good or moderate post-operative urinary flow. Post-void residual improved roughly 70 milliliters. 9.4% of patients required subsequent treatment; though 17.0% had recurrence defined by poor uroflow or self-reported poor stream. Small cohort size prevented establishing significance on hazard ratio assessment. Descriptively, strictures due to radiation had similar if not better response rate than those from other etiologies. CONCLUSIONS: With careful patient selection, urethral paclitaxel-coated balloon dilation is an easy and effective way to treat men with symptomatic urethral strictures. Although more research is needed, our data supports the possibility of using paclitaxel-coated balloon dilation in radiation induced strictures and in more than just the bulbar urethra. Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e911 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Kendrick Campbell More articles by this author Fernandino L. Vilson More articles by this author Sajya Singh More articles by this author Alethea Paradis More articles by this author Joel Vetter More articles by this author Gregory Murphy More articles by this author Expand All Advertisement PDF downloadLoading ...