Pd03-02 Small Molecule Gap Inhibitor Qs11 Promotes Adrenergic and Non-Adrenergic Prostate Smooth Muscle Contraction

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research Figure 1A), up to 49±21.9% for 1-100µM of phenylephrine-induced contractions (p<0.001 for QS11 vs. control; Figure 1B), and up to 58±17.6% for 1-100µM of methoxamine-induced contractions (p<0.001 for QS11 vs. control; Figure 1C). Additionally, QS11 promoted non-adrenergic contraction by thromboxane A2 analogue U46619 up to 55±37.4% for 1-300µM of U46619-induced contractions (p<0.001 for QS11 vs. control; Figure 1E) and EFS-induced neurogenic contractions up to 51±33.9% for 2-32 Hz (p=0.002 for QS11 vs. control; Figure 1F). However, there was no effect on endothelin-1 induced contractions (Figure 1D). CONCLUSIONS: QS11-sensitive GAPs are involved in regulation of human prostate smooth muscle contraction, by control of ARF6 GTPase activity. Knowledge about GEFs and GAPs involved in smooth muscle contraction is still limited. However, increased understanding of prostate smooth muscle contraction may assist in developing new pharmaceutical targets for LUTS medication in the future. Download PPT Source of Funding: None © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e76 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Alexander J. Tamalunas More articles by this author Amin Wendt More articles by this author Florian Springer More articles by this author Nikolaus Eitelberger More articles by this author Victor Vigodski More articles by this author Moritz Trieb More articles by this author Felix Schierholz More articles by this author Beata Rutz More articles by this author Anna Ciotkowska More articles by this author Giuseppe Magistro More articles by this author Christian G. Stief More articles by this author Martin Hennenberg More articles by this author Expand All Advertisement PDF downloadLoading ...