Melanoma Patient with Normal PSA and DRE with Suspicious Prostate FDG PET/CT Uptake Significant for Prostate Adenocarcinoma

A patient with a history of melanoma finds prostate adenocarcinoma after unexpected fluorodeoxyglucose (FDG) uptake on routine screening positron emission tomography (PET)/CT, despite having a normal prostate-specific antigen and digital rectal examination, underscoring the necessity of secondary imaging studies to adequately screen for prostate cancer in cases of prostatic uptake on FDG PET/CT.