Abstract 1005: A three-decade-long community-based participatory research among India and Bhutan’s ethnic minorities led to the discovery of 32 unique medicinal plants having anti-cancer properties

Abstract The country of Bhutan, and India’s Northeast is an economically deprived region inhabited by diverse groups of indigenous and underserved communities. They live in mostly rural areas, where cancer disparity is very high. On the other hand, they have rich traditional knowledge systems including tantra philosophies (remnant of the Vedic age philosophy), herbal medicinal practice, and spiritual practices that can be traced back to India’s Vedic age. To harness this traditional knowledge to reduce cancer disparity, we have taken an indigenous knowledge system (IKS) based approach (1) and initiated a community-based participatory research (CBPR) program in 1998 to conduct public health research in tuberculosis and cancer (2, 3). Using this CBPR program, we have unraveled a Vedic age philosophy of Vedic Jiva Upkara Cikitsha Tantra (Vedic altruism-based medicinal system) (2, 3). Specially, using the CBPR program we seek to identify novel herbal medicinal agents having anti-cancer activities. Methodologies: We used the CBPR methodologies of focused group discussion (FGD), debate, and community social work with various indigenous communities living in the Sualkuchi-Hajo cultural complex of Assam, Roing of Arunachal Pradesh, and Mongar of Bhutan. Since 1994, BD has conducted CBPR through the KaviKrishna Telemedicine Care. We have retrospectively analyzed the data of FGD, and suppositional reasoning (tarka) with the community healers, various Hindu, and Buddhist ethnic spiritual organizations of the region. Thematic analysis and the grounded theory method were applied to organize the data. The resulting database of herbal medicinal plants was searched in the scientific database to find the scientific names. Out of the 36 medicinal plants, we have prepared herbal extracts of 10 medicinal plants and then tested for their anti-cancer efficacy at the KaviKrishna Laboratory. Results: We have found the names of 32 plants used by the indigenous healers practicing the Vedic Jiva Upakara Cikitsha Tantra. We also found that these healers used curd-made whey protein concentrate, special soil, and fecal extracts to treat cancer (3). Our CBPR process also led to the research capacity building in the Sualkuchi-Hajo community. Conclusion: The study unraveled a unique cancer-care-related philosophy of Vedic Altruism. Our work indicates that IKS-based CBPR can equitably involve researchers and community members to develop a partnership for the process of knowledge emergence. We found that CBPR-based research takes new meaning because of the unique perspectives that inform the ways that research studies take shape for knowledge emergence. References: 1. Pathak L et al AACR abstract 3342, 2019. 2. Baishya T et al. https: //zenodo. org/records/8062404. 3. Pathak et al AACR abstract 2772, 2023 Citation Format: Sorra Sandhya, Rupam Das, Pragya Dutta, Avra Pratim Chowdhury, Pranjal Das, Sonali Das, Tutumoni Baishya, Lekhika Pathak, Debduti Dutta, Nihar Ranjan Das, Pranab Sarma, Ista Pulu, Ujjal Mahanta, Dayal Krishha Bora, Hem Bhai, Bikul Das. A three-decade-long community-based participatory research among India and Bhutan’s ethnic minorities led to the discovery of 32 unique medicinal plants having anti-cancer properties abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts) ; 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84 (6Suppl): Abstract nr 1005.