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Quantum mechanics has significantly advanced our understanding of fundamental properties. While biological studies have traditionally been assumed to be governed by classical physics, recent studies have shown that coherent excitonic coupling between two chromophores in a homodimer of the yellow fluorescent protein, Venus, is possible at room temperature Y. Kim et al., Biophys. J., 2019, 116, 1918-1930. In this study, we present a genetically encoded sensor, inspired by recent finding of the ultrafast photoinduced energy transfer between dimeric enhanced green fluorescent proteins (dEGFPs), to monitor hydrophobic environmental changes A. Sanchez-Pedreno Jimenez, et al., Phys. Chem. Chem. Phys., in press. This sensor can be used to investigate the spatial and temporal dynamics biocondensates in cells. This biosensor offers an innovative approach to unravel the dynamics of biocondensates, to elucidate their biological functions and potential implications in health and disease. Experiments are being conducted to test this sensor in living cells.
Jiménez et al. (Wed,) studied this question.