Key points are not available for this paper at this time.
In the February 26 issue, ADAW wrote about the “toolkit” on overdose prevention and rescue from the Substance Abuse and Mental Health Services Administration (SAMHSA) that calls for giving one dose (4 mg) of naloxone initially followed by a second dose two or three minutes later. The toolkit references studies that show increased doses of naloxone are not necessary in the fentanyl era. This is despite a study published in January from the U.S. Food and Drug Administration which found that 35% of overdose victims would die from that two‐to‐three‐minute wait for the second dose.
Alison Knopf (Fri,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: