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Abstract Objective Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disease. The aim of this study was to explore the effects of vitamin D supplementation on metabolic parameters of PCOS women. Methods A total of 60 PCOS women with vitamin D deficiency or insufficiency were enrolled in this randomized controlled trial. Participants were randomized to vitamin D group (2000 IU/day) or control group. The observational parameters were measured at baseline and after treatment (4 weeks, 8 weeks and 12 weeks), including body mass index (BMI), waist to hip ratio (WHR), blood pressure, oral glucose tolerance test (OGTT) and insulin release test, and lipid metabolism parameters. Results The serum 25(OH)D concentrations at different time points after vitamin D supplementation were significantly higher than that in control group (P P 0.05). Additionally, The serum insulin concentrations and HOMA-IR at different time points of OGTT, serum TG, TC and LDL-C concentrations in women of vitamin D group (obesity) were significantly lower than that in control group (obesity) (P 0.05). The BMI, WHR, TG, TC and LDL-C concentration in women of vitamin D group (IR) were significantly lower compared with control group (IR) (P 0.05). No significant difference was seen in metabolic parameters between vitamin D group (non-obesity) and control group (non-obesity) (P > 0.05), and these differences of metabolic parameters were also not observed between vitamin D group (non-IR) and control group (non-IR) (P > 0.05). Conclusion The findings of this study supported that vitamin D supplementation had beneficial effects on metabolic parameters of PCOS women, especially in women with obesity or IR.
Wen et al. (Tue,) studied this question.