723 Post-splenectomy neutrophil, lymphocytes, neutrophil to lymphocyte ratios and platelet to lymphocyte ratios and survival outcomes of advanced ovarian cancer patients

Introduction/Background Splenectomy exerts a detrimental effect on several heamatologic parameters including the numbers of platelets, neutrophils and lymphocytes.Current knowledge suggests an altered heamatological state that might influence patients survival.Platelet to lymphocyte(PLR) and neutrophil to lymphocyte(NLR) ratios have been traditionally considered promising screening and prognostic factors of EOC survival. In the present study we sought to determine whether post-splenectomy PLR and NLR values as well as their fluctuation compared to preoperative levels are correlated with ovarian cancer survival. Methodology The study was based on a retrospective chart review of OC patient records that had splenectomy as a part of their debulking procedure between 2016 and 2021.All patients that had maximal effort cytoreductive procedures(Surgical complexity score >4) were considered eligible. Postoperative counts were retrieved from laboratory tests performed at the 5th day following surgery.Correlations between preoperative and postoperative PLR and NLR values with survival as well of their differential values were calculated with the Spearman correlation, considering a level of significance Results Overall, 82 women were included in the present study. Pretreatment PLR values ranged between 165 and 832 with a median value of 280 and NLR values between 1 and 27 with a median value of 27.Postoperative PLR values were significantly larger compared to pretreatment(346 (177–1510)p=.027) as well as postoperative NLR values(8.8 (1.56, 327,p=.042).Correlation statistics did not reveal significant associations between preoperative, postoperative and differential values between preoperative and postoperative counts with PFS and OS.Similarly, there were no differences in crude values among patients that experienced relapse as well as those that died from the disease. Conclusion Differences in PLR and NLR values observed in splenectomized EOC patients do not seem to affect PFS and OS rates.Although considerable increases in both cases are observed following the procedure, these should not be considered prognostic, at least until further research becomes available. Disclosures Nothing to disclose.