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The issues with oral conventional dose forms can be resolved with the use of gastroretentive drug delivery systems (GRDDS). GRDDS is a way to prolong the stomach residence time, which allows for the release of drugs and the possibility of local or systemic effects in the upper gastrointestinal tract. To enhance treatment, some potent medications are employed with gastro-retentive dose forms for longer. By producing a high concentration of medication in the stomach that can be sustained for an extended amount of time, gastroretentive formulations (GRFs) greatly improve stomach pharmacotherapy. As a result, a wide range of dosage forms have been developed for medications that break down at alkaline pH but remain stable at acidic pH. Therefore, medications have limited absorption.
Wafa et al. (Fri,) studied this question.