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In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5)COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease.However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available.This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks.VE against COVID-19-associated ED/ UC encounters was 51% (95% CI = 47%-54%) during the first 7-59 days after an updated dose and 39% (95% CI = 33%-45%) during the 60-119 days after an updated dose.VE estimates against COVID-19-associated hospitalization from two CDC VE networks were 52% (95% CI = 47%-57%) and 43% (95% CI = 27%-56%), with a median interval from updated dose of 42 and 47 days, respectively.Updated COVID-19 vaccine provided increased protection against COVID-19associated ED/UC encounters and hospitalization among immunocompetent adults.These results support CDC recommendations for updated 2023-2024 COVID-19 vaccination.All persons aged ≥6 months should receive updated 2023-2024 COVID-19 vaccine.
DeCuir et al. (Thu,) studied this question.
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