Clinical characteristics and outcomes of patients who underwent neonatal cardiac surgery: ten years of experience in a tertiary surgery center

Abstract Objective To evaluate the outcomes after neonatal cardiac surgery at our institute, and identify factors associated with operative mortality. Methods We examined 224 neonates who underwent cardiac surgery at a single institution from 2013 to 2022. Relevant data, such as demographic information, operative details, and postoperative records, were gathered from medical and surgical records. Our primary focus was on the operative mortality. Results Median age and weight at surgery were 12 (7–20) days and 3.4 (3.0–3.8) kg, respectively. Overall mortality was 14.3% (32/224). Mortality rates showed improvement over time (2013–2017 vs. 2018–2022), with rates decreasing from 21.9% to 10.6% ( p = 0.023). ECMO use, extubation failure, lactate > 4.8 mmol/l and VIS > 15.5 on 24 h after operation were significantly associated with operative mortality, according to multivariate logistic regression analysis. Patients admitted to the cardiac intensive care unit (CICU) before surgery and those with prenatal diagnosis showed lower operative mortality. Median follow-up time of 192 hospital survivors was 28.0 (11.0–62.3) months. 10 patients experienced late deaths, and 7 patients required reinterventions after neonatal cardiac surgery. Risk factors for composite end-point of death and reintervention on multivariable analysis were: surgical period (HR = 0.230, 95% CI 0.081–0.654; p = 0.006), prolonged ventilation (HR = 4.792, 95% CI 1.296–16.177; p = 0.018) and STAT categories 3–5 (HR = 5.936, 95% CI 1.672–21.069; p = 0.006). Conclusions Our institution has observed improved surgical outcomes in neonatal cardiac surgery over the past five years with low mortality, but late death and reintervention remain necessary in some patients. The location and prenatal diagnosis prior to surgery may affect the outcomes of neonates undergoing congenital heart disease operations.