FIGURE 6 from Exhausted Tumor-infiltrating CD39+CD103+ CD8+ T Cells Unveil Potential for Increased Survival in Human Pancreatic Cancer

Effects of presurgical chemotherapy on the immune landscape. The immune landscape for patients that underwent upfront surgery (gray squares) was compared with the patients that underwent neoadjuvant chemotherapy followed by surgery (white squares). A, Kaplan–Meier survival curves comparing the two groups. B, Proportion of CD39+ CD103+ CD8+ T cells. C, Left, Proportion of CD4+ and CD8+ T cells out of CD45+ cells. Right, Ratio of cells in central tissues relative to peripheral and non-tumor tissues for CD4+ and CD8+ T cells out of CD45+ cells. Proportion of CD4+ T cells (D) and CD8+ T cells (E) expressing PD-1, TIM-3, CCR5, CXCR4, CXCR5, and CXCR3. F, Left, Proportion of CD19+ cells out of CD45+ cells. Right, Proportion of CD19 cells in central tissues relative to peripheral and non-tumor tissues. Mann–Whitney U test was used to detect statistically significant differences. *, P P P