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Abstract Background: Endometrial cancer (EC) tissues express CYP7B1, but its association with prognosis needs to be investigated. Methods: Immunohistochemistry and image analysis software were used to assess CYP7B1 protein expression in 307 paraffin-embedded endometrial tumor sections. Associations between CYP7B1 and clinical factors were tested with the Wilcoxon rank-sum test. Cox regression analysis was used to assess the association between CYP7B1 expression and the prognosis of patients with EC. Kaplan-Meier curves were employed to describe survival, and differences were assessed using the log-rank test. Results: A total of 307 patients were ultimately enrolled with an average age of 52.6±8.0 years at diagnosis. During follow-up, 46 patients (15.0%) died, and 29 (9.4%) suffered recurrence. The expression of CYP7B1 protein was significantly greater in the cytoplasm than in the nucleus. Higher levels of CYP7B1 protein were observed in patients aged Conclusions: High CYP7B1 protein expression predicted longer OS, suggesting that it may serve as an important molecular marker for predicting EC prognosis.
Lu et al. (Tue,) studied this question.