Introduction: This review explores the advancements in drug delivery systems using mi-crospheres, developed to overcome the limitations of traditional drug administration methods. Micro-spheres are engineered to deliver therapeutic agents to specific sites with controlled release, thereby improving treatment efficacy and reducing systemic side effects. Methodology: A comprehensive literature search was conducted using PubMed, Science Direct, Google Scholar, Bentham Science, Elsevier, Springer Nature, ResearchGate, Wikipedia, Frontiers, and Scribd. The search included English-language articles published between 2010 and 2025 using keywords such as “microspheres,” "drug delivery," "controlled release," "biodegradable polymers," "encapsulation," "targeted delivery," "vildagliptin microspheres," and "fenugreek extract delivery." A total of 119 articles were screened, and studies were selected based on their relevance to micro-sphere formulation techniques, polymer characteristics, drug release mechanisms, and their applica-tions. Result: Microspheres are being utilised as vehicles for transporting medicinal substances to particu-lar locations in controlled release systems. They are made up of synthetic polymers or proteins that degrade naturally. By combining the advantages of floating and high adhesiveness, microspheres can enhance the absorption into the bloodstream and regulate the release of medications, limiting dose regularity and improving conformity among patients. Using microspheres as a depot mechanism allows parenteral formulations to be administered under controlled conditions. Discussion: The utilisation of microspheres represents a significant advancement in drug delivery technology. Their ability to improve drug stability, bioavailability, and patient compliance has been well-documented. However, challenges such as manufacturing scalability and consistency remain key obstacles to widespread clinical adoption. Conclusion: Microspheres have sparked great curiosity about their ability to target various diseases. In the future, microspheres will be crucial for innovative medicine delivery by merging several meth-ods, particularly in the domains of genetic data and mutations, pathological cell categorisation, diag-nosis, reliable, effective, and targeted in vivo delivery, and additives that serve as microscopic models of the human body's damaged tissues and organs.
Srivastava et al. (Tue,) studied this question.