What type of study is this?

This is a In Vitro Study study.

December 4, 2025

An Anti-Inflammatory and Antioxidant Patch Based on Injectable Bioadhesive Hydrogel Prevents Postoperative Atrial Fibrillation

Key Points

Reduced atrial inflammation and oxidative stress following treatment with the hydrogel patch.
In vitro tests showed significant antioxidant effects on inflammation-sensitive cell lines and drug-responsive release rates.
Construction of an injectable bioadhesive hydrogel enabled targeted local drug delivery to cardiac tissue.
Results suggest that the proposed hydrogel may highlight a new therapeutic approach to minimizing postoperative atrial fibrillation.

Abstract

Postoperative atrial fibrillation (POAF) is a common surgical complication linked to atrial inflammation and oxidative stress. Here, we developed a strategy integrating chemical modification of therapeutics, poly(lactic-co-glycolic acid) (PLGA)-mediated sustained kinetics, and hydrogel-enabled spatial targeting to achieve continuous, local drug delivery to the atrial region. Andrographolide was modified with phenylboronic acid (PBAn) to change its solubility and enhance drug-loading capacity in PLGA microspheres, while enabling responsive drug release. We further constructed an injectable bioadhesive hydrogel via mixing of a copolymer and O-carboxymethyl chitosan, which adhered to cardiac tissue. In vitro, PBAn demonstrated ROS-responsive release, along with anti-inflammatory and antioxidant effects on RAW264.7 and HL-1 cells. In a rat pericarditis model, this localized system significantly reduced atrial inflammation and oxidative stress, promoted anti-inflammatory M2 macrophage polarization, enhanced electrical stability, and markedly decreased POAF susceptibility.

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