Gut Microbial Modulation as Precursor for Blood Glucose Regulation Through Moringa Oleifera Leaves Aqueous Extract—An Experimental Study

ABSTRACT Moringa oleifera (MO), also known as drumstick, has gained importance as a medicinal plant. In this experimental study, the prebiotic activity and glucose‐balancing potential of Moringa oleifera have been investigated. Twenty‐four male albino rats weighing 200–250 g were kept in the animal house. Streptozotocin‐induced diabetic rats were randomly divided into four groups ( n = 6 in each group). Control group ( G 0 ) rats were given Metformin 100 mg/kg/day, treatment groups G 1 , G 2 , and G 3 rats were provided with MO leaves extract 100, 200, and 300 mg/kg/day, respectively, with a standard basal diet, and were monitored twice a week for 21 days. The results of stool analysis showed the growth of Lactobacillus , which is evident by increased count of 10 4 CFU Lactobacillus in groups G 2 and G 3 compared to the control group 10 3 CFU Lactobacillus , while higher 10 5 CFU Lactobacillus were observed in group G 1 treated with 100 mg/kg/day of MO leaves extract. Anti‐hyperglycemic results are more evident on a dose of 100 mg/kg/day from 152.50 ± 7.7 to 119 ± 7.07 ( p value = 0.010) compared to other doses ( p > 0.05). This study's results conclude that Moringa oleifera has promising prebiotic and anti‐hyperglycemic properties and need further experimentation for a longer duration to establish the effective dose of Moringa oleifera .