March 28, 2014Open Access

Coronary artery disease severity and aortic stenosis: clinical outcomes according to SYNTAX score in patients undergoing transcatheter aortic valve implantation

Key Result

Patients with SYNTAX score > 22 have a higher risk of cardiovascular death, stroke, or MI at 1 year after TAVI compared to those without CAD or with low SYNTAX score.

Structured PICO

Does a high SYNTAX score (>22) increase the risk of cardiovascular death, stroke, or MI at 1 year in patients undergoing TAVI compared to those with no CAD or low SYNTAX score?

Population

Patients with aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)

Intervention

High SYNTAX score (SS > 22)

Comparator

No CAD or low SYNTAX score

Outcome

Composite of cardiovascular death, stroke, or MI at 1 yearcomposite

In patients undergoing TAVI, a high SYNTAX score (>22) is associated with less complete revascularization and a higher risk of adverse cardiovascular events at 1 year.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Severity of CAD appears to be associated with impaired clinical outcomes at 1 year after TAVI. Patients with SS > 22 receive less complete revascularization and have a higher risk of cardiovascular death, stroke, or MI than patients without CAD or low SS.